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GLP-1s and Endurance Performance: What Athletes Need to Know

Dec 10, 2025

GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) have quickly gained attention for their dramatic effects on weight loss and appetite control. But what happens when these medications enter the world of endurance sport? For triathletes and other athletes training long hours and pushing performance boundaries, the physiological impact of GLP-1 drugs could carry serious consequences. In this blog, we explore what GLP-1 medications are, how they work, and why their use in endurance athletes deserves careful consideration. Whether you're managing a medical condition or simply curious about emerging trends in performance and body composition, this article unpacks the current science, risks, and takeaways for the triathlon community.

What Are GLP-1 and GLP-1 Receptor Agonist Medications? 

Glucagon-like peptide-1 (GLP-1) is a hormone (an incretin) released from the gut after we eat. It helps regulate blood sugar by increasing insulin (when glucose is present) and reducing glucagon,...

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